From: <Saved by Microsoft Internet Explorer 5>
Subject: View
Date: Sat, 8 Jan 2005 10:16:05 -0800
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<HTML><HEAD><TITLE>IVOMEC=AE 1% INJECTION FOR CATTLE AND SWINE</TITLE>
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<BODY lang=3DEN-US style=3D"TEXT-JUSTIFY-TRIM: punctuation"><FONT =
size=3D5>MERIAL=20
LTD.</FONT><BR><B>3239 SATELLITE BLVD., DULUTH, GA, 30096</B><BR><IMG =
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    <TD><FONT class=3Dcommdatakey>Website:</FONT></TD>
    <TD width=3D30><FONT size=3D1>&nbsp;</FONT></TD>
    <TD><FONT =
class=3Dcommdatavalue>www.merial.com</FONT></TD></TR></TBODY></TABLE>
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<DIV class=3DSection1>
<P class=3DPName>IVOMEC<SUP>=AE</SUP></P>
<P class=3DMDist>Merial</P>
<P class=3DMsoNormal>NADA 128-409, Approved by the FDA</P>
<P class=3DMsoNormal><B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">(ivermectin)</SPAN></B></P>
<P class=3DMsoNormal><B>Injection for Cattle and Swine</B></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">1% =
Sterile=20
Solution</SPAN></B></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">A =
Parasiticide for=20
the Treatment and Control of Internal and External Parasites in Cattle =
and=20
Swine</SPAN></B></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">Consult =
your=20
veterinarian for assistance in the diagnosis, treatment and control of=20
parasitism.</SPAN></B></P>
<P class=3DMsoNormal><B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">INTRODUCTION</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">IVOMEC* =
(ivermectin) is=20
an injectable parasiticide for cattle and swine. One low-volume dose =
effectively=20
treats and controls the following internal and external parasites that =
may=20
impair the health of cattle and swine: gastrointestinal roundworms =
(including=20
inhibited <I>Ostertagia ostertagi</I> in cattle), lungworms, grubs, =
sucking=20
lice, and mange mites of cattle; and gastrointestinal roundworms, =
lungworms,=20
lice, and mange mites of swine. Discovered and developed by scientists =
from=20
Merck Research Laboratories, ivermectin is a novel chemical entity. Its=20
convenience, broad-spectrum efficacy, and safety margin make IVOMEC =
Injection a=20
unique product for parasite control of cattle and swine.</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">PRODUCT=20
DESCRIPTION</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Ivermectin =
is derived=20
from the avermectins, a family of potent, broad-spectrum antiparasitic =
agents=20
isolated from fermentation of <I>Streptomyces =
avermitilis</I>.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">IVOMEC =
Injection is a=20
clear, ready-to-use, sterile solution containing 1% ivermectin, 40% =
glycerol=20
formal, and propylene glycol, q.s. ad 100%. IVOMEC Injection is =
formulated to=20
deliver the recommended dose level of 200 mcg ivermectin/kilogram of =
body weight=20
in cattle when given subcutaneously at the rate of 1 mL/110 lb (50 kg). =
In=20
swine, IVOMEC Injection is formulated to deliver the recommended dose =
level of=20
300 mcg ivermectin/kilogram body weight when given subcutaneously in the =
neck at=20
the rate of 1 mL per 75 lb (33 kg).</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">MODE OF=20
ACTION</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Ivermectin =
is a member=20
of the macrocyclic lactone class of endectocides which have a unique =
mode of=20
action. Compounds of the class bind selectively and with high affinity =
to=20
glutamate-gated chloride ion channels which occur in invertebrate nerve =
and=20
muscle cells. This leads to an increase in the permeability of the cell =
membrane=20
to chloride ions with hyperpolarization of the nerve or muscle cell, =
resulting=20
in paralysis and death of the parasite. Compounds of this class may also =

interact with other ligand-gated chloride channels, such as those gated =
by the=20
neurotransmitter gamma-aminobutyric acid (GABA).</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">The wide =
margin of=20
safety is attributable to the fact that mammals do not have =
glutamate-gated=20
chloride channels, the macrocyclic lactones have a low affinity for =
other=20
mammalian ligand-gated chloride channels and they do not readily cross =
the=20
blood-brain barrier.</SPAN></P>
<P class=3DMsoNormal><B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">INDICATIONS</SPAN></B></P>
<P class=3DMsoNormal><B><U><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">Cattle:</SPAN></U></B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line"> IVOMEC Injection is indicated for the =
effective=20
treatment and control of the following harmful species of =
gastrointestinal=20
roundworms, lungworms, grubs, sucking lice, and mange mites in=20
cattle:</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Gastrointestinal=20
Roundworms</SPAN></B><SPAN style=3D"LAYOUT-GRID-MODE: line"> (adults and =

fourth-stage larvae):</SPAN></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Ostertagia=20
ostertagi</SPAN></I><SPAN style=3D"LAYOUT-GRID-MODE: line"> (including =
inhibited=20
<I>O. ostertagi)</I></SPAN></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: line">O.=20
lyrata</SPAN></I></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Haemonchus=20
placei</SPAN></I></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Trichostrongylus=20
axei</SPAN></I></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: line">T.=20
colubriformis</SPAN></I></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: line">Cooperia=20
oncophora</SPAN></I></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: line">C.=20
punctata</SPAN></I></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: line">C.=20
pectinata</SPAN></I></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Oesophagostomum=20
radiatum</SPAN></I></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Bunostomum=20
phlebotomum</SPAN></I></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Nematodirus=20
helvetianus </SPAN></I><SPAN style=3D"LAYOUT-GRID-MODE: line">(adults=20
only)</SPAN></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: line">N. =
spathiger=20
</SPAN></I><SPAN style=3D"LAYOUT-GRID-MODE: line">(adults =
only)</SPAN></P>
<P class=3DMsoNormal><B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">Lungworms</SPAN></B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line"> (adults and fourth-stage =
larvae):</SPAN></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Dictyocaulus=20
viviparus</SPAN></I></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">Cattle =
Grubs=20
</SPAN></B><SPAN style=3D"LAYOUT-GRID-MODE: line">(parasitic =
stages):</SPAN></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: line">Hypoderma =

bovis</SPAN></I></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: line">H.=20
lineatum</SPAN></I></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">Sucking=20
Lice</SPAN></B><SPAN style=3D"LAYOUT-GRID-MODE: line">:</SPAN></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Linognathus=20
vituli</SPAN></I></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Haematopinus=20
eurysternus</SPAN></I></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Solenopotes=20
capillatus</SPAN></I></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">Mites=20
</SPAN></B><SPAN style=3D"LAYOUT-GRID-MODE: line">(scabies):</SPAN></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: line">Psoroptes =
ovis=20
</SPAN></I><SPAN style=3D"LAYOUT-GRID-MODE: line">(syn. <I>P. =
communis</I> var.=20
<I>bovis)</I></SPAN></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: line">Sarcoptes =

scabiei</SPAN></I><SPAN style=3D"LAYOUT-GRID-MODE: line"> var.=20
<I>bovis</I></SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Persistent=20
Activity</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">IVOMEC =
Injection has=20
been proved to effectively control infections and to protect cattle from =

reinfection with <I>Dictyocaulus viviparus</I> for 28 days after =
treatment;=20
<I>Ostertagia ostertagi</I> for 21 days after treatment; =
<I>Oesophagostomum=20
radiatum, Haemonchus placei, Trichostrongylus axei, Cooperia =
punctata</I>, and=20
<I>Cooperia oncophora</I> for 14 days after treatment.</SPAN></P>
<P class=3DMsoNormal><B><U><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">Swine:</SPAN></U></B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line"> IVOMEC Injection is indicated for the =
effective=20
treatment and control of the following harmful species of =
gastrointestinal=20
roundworms, lungworms, lice, and mange mites in swine:</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Gastrointestinal=20
Roundworms:</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Large =
roundworm,=20
<I>Ascaris suum</I></SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">(adults and =
fourth-stage=20
larvae)</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Red stomach =
worm,=20
<I>Hyostrongylus rubidus</I></SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">(adults and =
fourth-stage=20
larvae)</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Nodular =
worm,=20
<I>Oesophagostomum</I> spp.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">(adults and =
fourth-stage=20
larvae)</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Threadworm,=20
<I>Strongyloides ransomi </I>(adults)</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">Somatic =
Roundworm=20
Larvae:</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Threadworm,=20
<I>Strongyloides ransomi</I> (somatic larvae)</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Sows must be =
treated at=20
least seven days before farrowing to prevent infection in =
piglets.</SPAN></P>
<P class=3DMsoNormal><B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">Lungworms:</SPAN></B></P>
<P class=3DMsoNormal><I><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">Metastrongylus</SPAN></I><SPAN=20
style=3D"LAYOUT-GRID-MODE: line"> spp. (adults)</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Lice:</SPAN></B></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Haematopinus=20
suis</SPAN></I></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">Mange=20
Mites:</SPAN></B></P>
<P class=3DMsoNormal><I><SPAN style=3D"LAYOUT-GRID-MODE: line">Sarcoptes =

scabiei</SPAN></I><SPAN style=3D"LAYOUT-GRID-MODE: line"> var.=20
<I>suis</I></SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: =
line">DOSAGE</SPAN></B></P>
<P class=3DMsoNormal><B><U><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">Cattle:</SPAN></U></B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line"> IVOMEC Injection should be given only =
by=20
subcutaneous injection under the loose skin in front of or behind the =
shoulder=20
at the recommended dose level of 200 mcg ivermectin per kilogram of body =
weight.=20
Each mL of IVOMEC contains 10 mg of ivermectin, sufficient to treat =
110&nbsp;lb=20
(50&nbsp;kg) of body weight (maximum 10 mL per injection =
site).</SPAN></P>
<TABLE class=3DMsoNormalTable=20
style=3D"BORDER-RIGHT: medium none; BORDER-TOP: medium none; =
BORDER-LEFT: medium none; BORDER-BOTTOM: medium none; BORDER-COLLAPSE: =
collapse"=20
cellSpacing=3D0 cellPadding=3D0 border=3D1>
  <TBODY>
  <TR>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; BORDER-LEFT: windowtext 1pt solid; WIDTH: 101.5pt; PADDING-TOP: =
0in; BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D135>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><B><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">Body =
Weight<BR>(lb)</SPAN></B></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; BORDER-LEFT: medium none; WIDTH: 110.8pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D148>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><B><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">Dose =
Volume<BR>(mL)</SPAN></B></P></TD></TR>
  <TR>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: windowtext 1pt solid; WIDTH: 101.5pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D135>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">220</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 110.8pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D148>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">2</SPAN></P></TD></TR>
  <TR>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: windowtext 1pt solid; WIDTH: 101.5pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D135>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">330</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 110.8pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D148>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">3</SPAN></P></TD></TR>
  <TR>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: windowtext 1pt solid; WIDTH: 101.5pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D135>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">440</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 110.8pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D148>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">4</SPAN></P></TD></TR>
  <TR>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: windowtext 1pt solid; WIDTH: 101.5pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D135>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">550</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 110.8pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D148>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">5</SPAN></P></TD></TR>
  <TR>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: windowtext 1pt solid; WIDTH: 101.5pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D135>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">660</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 110.8pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D148>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">6</SPAN></P></TD></TR>
  <TR>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: windowtext 1pt solid; WIDTH: 101.5pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D135>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">770</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 110.8pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D148>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">7</SPAN></P></TD></TR>
  <TR>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: windowtext 1pt solid; WIDTH: 101.5pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D135>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">880</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 110.8pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D148>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">8</SPAN></P></TD></TR>
  <TR>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: windowtext 1pt solid; WIDTH: 101.5pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D135>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">990</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 110.8pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D148>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">9</SPAN></P></TD></TR>
  <TR>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: windowtext 1pt solid; WIDTH: 101.5pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D135>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">1100</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 110.8pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D148>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: =
line">10</SPAN></P></TD></TR></TBODY></TABLE>
<P class=3DMsoNormal><B><U><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">Swine:</SPAN></U></B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line"> IVOMEC Injection should be given only =
by=20
subcutaneous injection in the neck of swine at the recommended dose =
level of 300=20
mcg of ivermectin per kilogram (2.2 lb) of body weight. Each mL of =
IVOMEC=20
contains 10 mg of ivermectin, sufficient to treat 75 lb of body=20
weight.</SPAN></P>
<TABLE class=3DMsoNormalTable=20
style=3D"BORDER-RIGHT: medium none; BORDER-TOP: medium none; =
BORDER-LEFT: medium none; BORDER-BOTTOM: medium none; BORDER-COLLAPSE: =
collapse"=20
cellSpacing=3D0 cellPadding=3D0 border=3D1>
  <TBODY>
  <TR>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; BORDER-LEFT: windowtext 1pt solid; WIDTH: 117.9pt; PADDING-TOP: =
0in; BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D157>
      <P class=3DMsoNormal><B><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line"></SPAN></B>&nbsp;</P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; BORDER-LEFT: medium none; WIDTH: 99pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D132>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><B><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">Body =
Weight<BR>(lb)</SPAN></B></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: windowtext 1pt solid; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; BORDER-LEFT: medium none; WIDTH: 95.3pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D127>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><B><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">Dose =
Volume<BR>(mL)</SPAN></B></P></TD></TR>
  <TR style=3D"page-break-inside: avoid">
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: windowtext 1pt solid; WIDTH: 117.9pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D157 rowSpan=3D4>
      <P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Growing=20
      Pigs</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 99pt; PADDING-TOP: 0in; BORDER-BOTTOM: =
windowtext 1pt solid"=20
    vAlign=3Dtop width=3D132>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">19</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 95.3pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D127>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">1/4</SPAN></P></TD></TR>
  <TR style=3D"page-break-inside: avoid">
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 99pt; PADDING-TOP: 0in; BORDER-BOTTOM: =
windowtext 1pt solid"=20
    vAlign=3Dtop width=3D132>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">38</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 95.3pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D127>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">1/2</SPAN></P></TD></TR>
  <TR style=3D"page-break-inside: avoid">
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 99pt; PADDING-TOP: 0in; BORDER-BOTTOM: =
windowtext 1pt solid"=20
    vAlign=3Dtop width=3D132>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">75</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 95.3pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D127>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">1</SPAN></P></TD></TR>
  <TR style=3D"page-break-inside: avoid">
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 99pt; PADDING-TOP: 0in; BORDER-BOTTOM: =
windowtext 1pt solid"=20
    vAlign=3Dtop width=3D132>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">150</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 95.3pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D127>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">2</SPAN></P></TD></TR>
  <TR style=3D"page-break-inside: avoid">
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: windowtext 1pt solid; WIDTH: 117.9pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D157 rowSpan=3D4>
      <P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Breeding=20
      Animals<BR>(Sows, Gilts, and Boars)</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 99pt; PADDING-TOP: 0in; BORDER-BOTTOM: =
windowtext 1pt solid"=20
    vAlign=3Dtop width=3D132>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">225</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 95.3pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D127>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">3</SPAN></P></TD></TR>
  <TR style=3D"page-break-inside: avoid">
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 99pt; PADDING-TOP: 0in; BORDER-BOTTOM: =
windowtext 1pt solid"=20
    vAlign=3Dtop width=3D132>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">300</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 95.3pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D127>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">4</SPAN></P></TD></TR>
  <TR style=3D"page-break-inside: avoid">
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 99pt; PADDING-TOP: 0in; BORDER-BOTTOM: =
windowtext 1pt solid"=20
    vAlign=3Dtop width=3D132>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">375</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 95.3pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D127>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">5</SPAN></P></TD></TR>
  <TR style=3D"page-break-inside: avoid">
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 99pt; PADDING-TOP: 0in; BORDER-BOTTOM: =
windowtext 1pt solid"=20
    vAlign=3Dtop width=3D132>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">450</SPAN></P></TD>
    <TD=20
    style=3D"BORDER-RIGHT: windowtext 1pt solid; PADDING-RIGHT: 5.4pt; =
BORDER-TOP: medium none; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: 0in; =
BORDER-LEFT: medium none; WIDTH: 95.3pt; PADDING-TOP: 0in; =
BORDER-BOTTOM: windowtext 1pt solid"=20
    vAlign=3Dtop width=3D127>
      <P class=3DMsoNormal style=3D"TEXT-ALIGN: center" =
align=3Dcenter><SPAN=20
      style=3D"LAYOUT-GRID-MODE: =
line">6</SPAN></P></TD></TR></TBODY></TABLE>
<P class=3DMsoNormal><B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">ADMINISTRATION</SPAN></B></P>
<P class=3DMsoNormal><B><U><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">Cattle:</SPAN></U><SPAN=20
style=3D"LAYOUT-GRID-MODE: line"> IVOMEC Injection is to be given =
subcutaneously=20
only, to reduce risk of potentially fatal clostridial infection of the =
injection=20
site.</SPAN></B><SPAN style=3D"LAYOUT-GRID-MODE: line"> Animals should =
be=20
appropriately restrained to achieve the proper route of administration. =
Use of a=20
16-gauge 1/2" to 3/4" needle is suggested. Inject under the loose skin =
in front=20
of or behind the shoulder (see illustration).</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"FONT-SIZE: 10pt; LAYOUT-GRID-MODE: =
line"><IMG=20
height=3D14=20
src=3D"http://valleyvet.naccvp.com/view_label_image.php?prodnum=3D1111031=
&amp;img=3D11110312_i1.gif"=20
width=3D15></SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">When using =
the 200, 500=20
or 1000 mL pack size, use only automatic syringe equipment.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Use sterile =
equipment=20
and sanitize the injection site by applying a suitable disinfectant. =
Clean,=20
properly disinfected needles should be used to reduce the potential for=20
injection site infections.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">No special =
handling or=20
protective clothing is necessary.</SPAN></P>
<P class=3DMsoNormal><B><U><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">Swine:</SPAN></U></B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line"> IVOMEC<SUP>=AE</SUP> (ivermectin) =
Injection is to=20
be given subcutaneously in the neck. Animals should be appropriately =
restrained=20
to achieve the proper route of administration. Use of a 16- or 18-gauge =
needle=20
is suggested for sows and boars, while an 18- or 20-gauge needle may be=20
appropriate for young animals. Inject under the skin, immediately behind =
the ear=20
(see illustration).</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"FONT-SIZE: 10pt; LAYOUT-GRID-MODE: =
line"><IMG=20
height=3D14=20
src=3D"http://valleyvet.naccvp.com/view_label_image.php?prodnum=3D1111031=
&amp;img=3D11110312_i2.gif"=20
width=3D15></SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">When using =
the 200 mL,=20
500 mL or 1000 mL pack size, use only automatic syringe equipment. As =
with any=20
injection, sterile equipment should be used. The injection site should =
be=20
cleaned and disinfected with alcohol before injection. The rubber =
stopper should=20
also be disinfected with alcohol to prevent contamination of the =
contents. Mild=20
and transient pain reactions may be seen in some swine following =
subcutaneous=20
administration.</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Recommended Treatment=20
Program</SPAN></B></P>
<P class=3DMsoNormal><B><U><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">Swine:</SPAN></U></B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line"> At the time of initiating any parasite =
control=20
program, it is important to treat all breeding animals in the herd. =
After the=20
initial treatment, use IVOMEC Injection regularly as follows:</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">BREEDING=20
ANIMALS</SPAN></B></P>
<TABLE class=3DMsoNormalTable style=3D"BORDER-COLLAPSE: collapse" =
cellSpacing=3D0=20
cellPadding=3D0 border=3D0>
  <TBODY>
  <TR>
    <TD=20
    style=3D"PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; WIDTH: 0.7in; PADDING-TOP: 0in"=20
    vAlign=3Dtop width=3D67>
      <P class=3DMsoNormal><B><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">Sows:</SPAN></B></P></TD>
    <TD=20
    style=3D"PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; WIDTH: 5.45in; PADDING-TOP: 0in"=20
    vAlign=3Dtop width=3D523>
      <P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Treat =
prior to=20
      farrowing, preferably 7-14 days before, to minimize infection of=20
      piglets.</SPAN></P></TD></TR>
  <TR>
    <TD=20
    style=3D"PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; WIDTH: 0.7in; PADDING-TOP: 0in"=20
    vAlign=3Dtop width=3D67>
      <P class=3DMsoNormal><B><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">Gilts:</SPAN></B></P></TD>
    <TD=20
    style=3D"PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; WIDTH: 5.45in; PADDING-TOP: 0in"=20
    vAlign=3Dtop width=3D523>
      <P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Treat =
7-14 days=20
      prior to breeding.<BR>Treat 7-14 days prior to =
farrowing.</SPAN></P></TD></TR>
  <TR>
    <TD=20
    style=3D"PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; WIDTH: 0.7in; PADDING-TOP: 0in"=20
    vAlign=3Dtop width=3D67>
      <P class=3DMsoNormal><B><SPAN=20
      style=3D"LAYOUT-GRID-MODE: line">Boars:</SPAN></B></P></TD>
    <TD=20
    style=3D"PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; WIDTH: 5.45in; PADDING-TOP: 0in"=20
    vAlign=3Dtop width=3D523>
      <P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Frequency and need=20
      for treatments are dependent upon exposure.<BR>Treat at least two =
times a=20
      year.</SPAN></P></TD></TR></TBODY></TABLE>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">FEEDER=20
PIGS</SPAN></B></P>
<P class=3DMsoNormal><B><SPAN=20
style=3D"LAYOUT-GRID-MODE: =
line">(Weaners/Growers/Finishers)</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">All =
weaner/feeder pigs=20
should be treated before placement in clean quarters.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Pigs exposed =
to=20
contaminated soil or pasture may need retreatment if reinfection=20
occurs.</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: =
line">NOTE:</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">(1) IVOMEC =
Injection has=20
a persistent drug level sufficient to control mite infestations =
throughout the=20
egg to adult life cycle. However, since the ivermectin effect is not =
immediate,=20
care must be taken to prevent reinfestation from exposure to untreated =
animals=20
or contaminated facilities. Generally, pigs should not be moved to clean =

quarters or exposed to uninfested pigs for approximately one week after=20
treatment. Sows should be treated at least one week before farrowing to =
minimize=20
transfer of mites to newborn baby pigs.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">(2) Louse =
eggs are=20
unaffected by IVOMEC Injection and may require up to three weeks to =
hatch. Louse=20
infestations developing from hatching eggs may require =
retreatment.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">(3) Consult =
a=20
veterinarian for aid in the diagnosis and control of internal and =
external=20
parasites of swine.</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">Special =
Minor=20
Use</SPAN></B></P>
<P class=3DMsoNormal><B><U><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">Reindeer:</SPAN></U></B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line"> For the treatment and control of =
warbles=20
<I>(Oedemagena tarandi)</I> in reindeer, inject 200 micrograms =
ivermectin per=20
kilogram of body weight, subcutaneously. Follow use directions for =
cattle as=20
described under <B>ADMINISTRATION</B>.</SPAN></P>
<P class=3DMsoNormal><B><U><SPAN style=3D"LAYOUT-GRID-MODE: =
line">American=20
Bison:</SPAN></U></B><SPAN style=3D"LAYOUT-GRID-MODE: line"> For the =
treatment and=20
control of grubs <I>(Hypoderma bovis)</I> in American bison, inject 200=20
micrograms ivermectin per kilogram of body weight, subcutaneously. =
Follow use=20
directions for cattle as described under =
<B>ADMINISTRATION</B>.</SPAN></P>
<TABLE class=3DMsoNormalTable style=3D"BORDER-COLLAPSE: collapse" =
cellSpacing=3D0=20
cellPadding=3D0 border=3D0>
  <TBODY>
  <TR>
    <TD=20
    style=3D"PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; WIDTH: 30.25pt; PADDING-TOP: 0in"=20
    vAlign=3Dtop width=3D40>
      <P class=3DMsoNormal><SPAN=20
      style=3D"FONT-SIZE: 10pt; LAYOUT-GRID-MODE: line"><IMG height=3D30 =

      =
src=3D"http://valleyvet.naccvp.com/view_label_image.php?prodnum=3D1111031=
&amp;img=3D11110312_i3.gif"=20
      width=3D9></SPAN></P></TD>
    <TD=20
    style=3D"PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; WIDTH: 5in; PADDING-TOP: 0in"=20
    vAlign=3Dtop width=3D480>
      <P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: =
line">RESIDUE=20
      INFORMATION: </SPAN></B><SPAN style=3D"LAYOUT-GRID-MODE: line">Do =
not treat=20
      reindeer or American bison within 8 weeks (56 days) of=20
      slaughter.</SPAN></P></TD>
    <TD=20
    style=3D"PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; WIDTH: 31.2pt; PADDING-TOP: 0in"=20
    vAlign=3Dtop width=3D42>
      <P class=3DMsoNormal><SPAN=20
      style=3D"FONT-SIZE: 10pt; LAYOUT-GRID-MODE: line"><IMG height=3D30 =

      =
src=3D"http://valleyvet.naccvp.com/view_label_image.php?prodnum=3D1111031=
&amp;img=3D11110312_i4.gif"=20
      width=3D10></SPAN></P></TD></TR></TBODY></TABLE>
<P class=3DMsoNormal><B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">WARNING</SPAN></B></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">Not for =
use in=20
humans.</SPAN></B></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">Keep this =
and all=20
drugs out of the reach of children.</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">The Material =
Safety Data=20
Sheet (MSDS) contains more detailed occupational safety information. To =
report=20
adverse effects, obtain an MSDS or for assistance, contact Merial at=20
1-888-637-4251.</SPAN></P>
<TABLE class=3DMsoNormalTable style=3D"BORDER-COLLAPSE: collapse" =
cellSpacing=3D0=20
cellPadding=3D0 border=3D0>
  <TBODY>
  <TR>
    <TD=20
    style=3D"PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; WIDTH: 34.95pt; PADDING-TOP: 0in"=20
    vAlign=3Dtop width=3D47>
      <P class=3DMsoNormal><SPAN=20
      style=3D"FONT-SIZE: 10pt; LAYOUT-GRID-MODE: line"><IMG height=3D73 =

      =
src=3D"http://valleyvet.naccvp.com/view_label_image.php?prodnum=3D1111031=
&amp;img=3D11110312_i5.gif"=20
      width=3D23></SPAN></P></TD>
    <TD=20
    style=3D"PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; WIDTH: 5in; PADDING-TOP: 0in"=20
    vAlign=3Dtop width=3D480>
      <P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: =
line">RESIDUE=20
      INFORMATION:</SPAN></B><SPAN style=3D"LAYOUT-GRID-MODE: line"> Do =
not treat=20
      cattle within 35 days of slaughter. Because a withdrawal time in =
milk has=20
      not been established, do not use in female dairy cattle of =
breeding=20
      age.<BR>Do not treat swine within 18 days of =
slaughter.</SPAN></P></TD>
    <TD=20
    style=3D"PADDING-RIGHT: 5.4pt; PADDING-LEFT: 5.4pt; PADDING-BOTTOM: =
0in; WIDTH: 34.95pt; PADDING-TOP: 0in"=20
    vAlign=3Dtop width=3D47>
      <P class=3DMsoNormal><SPAN=20
      style=3D"FONT-SIZE: 10pt; LAYOUT-GRID-MODE: line"><IMG height=3D73 =

      =
src=3D"http://valleyvet.naccvp.com/view_label_image.php?prodnum=3D1111031=
&amp;img=3D11110312_i6.gif"=20
      width=3D23></SPAN></P></TD></TR></TBODY></TABLE>
<P class=3DMsoNormal><B><SPAN=20
style=3D"LAYOUT-GRID-MODE: line">PRECAUTIONS</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Transitory =
discomfort=20
has been observed in some cattle following subcutaneous administration. =
A low=20
incidence of soft tissue swelling at the injection site has been =
observed. These=20
reactions have disappeared without treatment. For cattle, divide doses =
greater=20
than 10 mL between two injection sites to reduce occasional discomfort =
or site=20
reaction.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Use sterile =
equipment=20
and sanitize the injection site by applying a suitable disinfectant. =
Clean,=20
properly disinfected needles should be used to reduce the potential for=20
injection site infections.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Observe =
cattle for=20
injection site reactions. Reactions may be due to clostridial infection =
and=20
should be aggressively treated with appropriate antibiotics. If =
injection site=20
infections are suspected, consult your veterinarian.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">This product =
is not for=20
intravenous or intramuscular use.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Protect =
product from=20
light.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">IVOMEC =
Injection for=20
Cattle and Swine has been developed specifically for use in cattle, =
swine,=20
reindeer and American bison <B>only</B>. This product should not be used =
in=20
other animal species as severe adverse reactions, including fatalities =
in dogs,=20
may result.</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">When to =
Treat Cattle=20
with Grubs</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">IVOMEC =
effectively=20
controls all stages of cattle grubs. However, proper timing of treatment =
is=20
important. For most effective results, cattle should be treated as soon =
as=20
possible after the end of the heel fly (warble fly) season. Destruction =
of=20
<I>Hypoderma</I> larvae (cattle grubs) at the period when these grubs =
are in=20
vital areas may cause undesirable host-parasite reactions including the=20
possibility of fatalities. Killing <I>Hypoderma lineatum</I> when it is =
in the=20
tissue surrounding the esophagus (gullet) may cause salivation and =
bloat;=20
killing <I>H. bovis</I> when it is in the vertebral canal may cause =
staggering=20
or paralysis. These reactions are not specific to treatment with IVOMEC, =
but can=20
occur with any successful treatment of grubs. Cattle should be treated =
either=20
before or after these stages of grub development. Consult your =
veterinarian=20
concerning the proper time for treatment.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Cattle =
treated with=20
IVOMEC after the end of the heel fly season may be retreated with IVOMEC =
during=20
the winter for internal parasites, mange mites, or sucking lice without =
danger=20
of grub-related reactions. A planned parasite control program is=20
recommended.</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: =
line">Environmental=20
Safety</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Studies =
indicate that=20
when ivermectin comes in contact with the soil, it readily and tightly =
binds to=20
the soil and becomes inactive over time. Free ivermectin may adversely =
affect=20
fish and certain water-borne organisms on which they feed. Do not permit =
water=20
runoff from feedlots or production sites to enter lakes, streams, or =
ponds. Do=20
not contaminate water by direct application or by the improper disposal =
of drug=20
containers. Dispose of containers in an approved landfill or by=20
incineration.</SPAN></P>
<P class=3DMsoNormal><B><SPAN style=3D"LAYOUT-GRID-MODE: line">HOW=20
SUPPLIED</SPAN></B></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">IVOMEC =
Injection for=20
Cattle and Swine is available in five ready-to-use pack =
sizes:</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">The 50 mL =
pack is a=20
multiple dose, rubber-capped bottle. Each bottle contains sufficient =
solution to=20
treat 10 head of 550 lb (250 kg) cattle or 100 head of 38 lb (17.3 kg)=20
swine.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">The 200 mL =
pack is a=20
soft, collapsible pack designed for use with automatic syringe =
equipment. Each=20
pack contains sufficient solution to treat 40 head of 550 lb (250 kg) =
cattle or=20
400 head of 38 lb (17.3 kg) swine.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">The 500 mL =
pack is a=20
soft, collapsible pack designed for use with automatic syringe =
equipment. Each=20
pack contains sufficient solution to treat 100 head of 550 lb (250 kg) =
cattle or=20
1000 head of 38 lb (17.3 kg) swine.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">The 2x 500 =
mL includes=20
two 500 mL packs with sufficient solution to treat 200 head of 550 lb =
(250 kg)=20
cattle or 2000 head of 38 lb (17.3 kg) swine.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">The 1000 mL =
pack is a=20
soft, collapsible pack designed for use with automatic syringe =
equipment. Each=20
pack contains sufficient solution to treat 200 head of 550 lb (250 kg) =
cattle or=20
2000 head of 38 lb (17.3 kg) swine.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: =
line">*<B>IVOMEC,</B> Cattle=20
Head Logo and Pig Head Logo are registered trademarks of =
Merial.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">(Merial =
Limited:=20
Registered in England and Wales [Reg. No. 3332751] with registered =
offices at 27=20
Knightsbridge, London, SW1X 7QT, England and domesticated in Delaware, =
USA as=20
Merial LLC).</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Merial=20
Limited</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">Iselin, NJ,=20
U.S.A.</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">U.S. Pat. =
4,199,569=20
&amp; 4,853,372</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: line">November =
1999</SPAN></P>
<P class=3DMsoNormal><SPAN style=3D"LAYOUT-GRID-MODE: =
line">8913412</SPAN></P>
<P class=3DCCNum>Disclaimer: Every effort has been made to ensure the =
accuracy of=20
the information published. However, it remains the responsibility of the =
readers=20
to familiarize themselves with the product information contained on the =
product=20
label or package insert. NAC No.: 11110312</P></DIV><BR><!---Generated: =
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